Abstract no.: 775

Evaluation of trace elements and some enzymes in Egyptian children with Down syndrome
N.A. Meguid, H.H.Afifi & N. Kholosy

The present study investigated the activity of Cu Zn superoxide dismutase in red blood cells and glutathione peroxidase (GPx) in whole blood using spectrophotometric methods. The plasma levels of the copper and zinc cofactors, and whole blood selenium were evaluated using a population of 15 patients with Down Syndrome (DS) with complete trisomy 21 (group 1), translocations (group 2) and mosaicism (group 3), and 15 controls matched for age and sex.

The purpose of this work was to study the gene dosage effect of SOD and its effect on glutathione peroxidase enzyme, and to find out its correlation with developmental fields. The results show that SOD and GPx activities were increased in the population with complete trisomy 21 and translocations, while in cases with mosaicism, the enzyme activities were within normal limits. Plasma copper concentrations were significantly decreased in the three groups with DS.

Although the present results require very subtle interpretation, these findings are powerful tools for identifying nutritional status and guiding antioxidant intervention.

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This entry was posted on Wednesday, September 21st, 2011 at 5:43 pm. Both comments and pings are currently closed.