Nutrivene Brain NRG
Brain NRG is a high-potency combination of the nutrients most proven to support energy generation and utilization in the brain. This formula was developed by Dr. Parris Kidd, from his extensive research into brain physiology and biochemistry. It contains exclusively ortho molecules - nutrients that occur naturally in the brain. The human brain has huge energy requirements - while representing only about 2% of the body’s weight it uses at least 20% of the body’s oxygen and blood sugar.(1)
Declining brain performance typically is accompanied by brain energy decline.(2) This formula provides ample supplies of nutrients to support the various categories of human brain energy production and utilization, including: 1. Oxygen-linked (“aerobic”) energy production. This is done only by mitochondria, the mini-power plants inside our cells, and accounts for the bulk of brain energy production.(3) 2. Anaerobic energy production (glycolysis), which occurs in the cell cytoplasm (water phase).(3) 3. Energy utilization for “housekeeping”—to maintain the basal activities of the brain’s approximately one trillion cells (100 billion nerve cells and 900-plus billion other cells).(4) A big chunk of this housekeeping energy goes to maintaining the sodium-potassium ion pumps that keep the nerve cell membranes primed to produce electrical signals.(1) 4. Energy utilization for signaling. This consumes well over 80% of the brain’s energy, and includes (1) making and packaging the nerve transmitters to activate information exchange at the synapses; (2) re-activating the ion pumps after synapse activation has occurred; (3) recycling of the transmitters following their release.(1)
The nutrients in Brain NRG are chemically identical to the forms naturally present in all human cells. Two-time Nobel prizewinner Linus Pauling named these ortho molecules, for “molecules orthodox” to the body.(5) Their integral relationships with healthy human biochemistry make the ortho molecules generally the most effective AND safest ingredients for dietary supplements.
This formula provides:
Coenzyme Q10 (CoQ10), the pre-eminent electron transport nutrient AND a potent antioxidant.(6) All our cells carry multiple mitochondria, each equipped with a double set of membranes to manage its energy production functions.(3) Each membrane has a thin molecular sheet or matrix that consists mostly of phospholipid molecules and provides the structural foundation for the numerous membrane enzymes and other catalytic proteins.(3) Within the matrix, CoQ10 molecules zip around at dazzling speed. They pick up high-energy electrons extracted from food molecules and deliver them to membrane enzymes that capture the electronic energy and transform it into the chemical energy of ATP (adenosine triphosphate, the energy currency of the body).(3) CoQ10 also helps protects the mitochondria membranes against free-radical “burn” damage from these activated electrons.(2) CoQ10’s central role in brain energetics is validated by decades of research.(7)
PhosphatidylSerine (PS), a phospholipid nutrient and a major cell membrane building block.(11) PS is a vital lipid both for the membranes that power the mitochondria and for all other cell membranes. PS is the most clinically proven brain nutrient: numerous double-blind clinical trials indicate it supports memory, learning, and the other cognitive brain functions.(11,12) PS also helps manage stress, anxiety and mood.(13) PS helps conserve the receptors in the nerve cell membranes that respond to NGF (nerve growth factor), which helps maintain and enhance nerve cell survival and renewal.(11,14)
GlyceroPhosphoCholine (GPC), another vital phospholipid nutrient.(15) GPC is present in the cell water phase, where it protects against waste product buildup. GPC is a highly bioavailable source of choline, a nutrient essential for epigenetic gene regulation and for the production of acetylcholine, a key nerve transmitter. GPC supports attention, memory, and other cognitive functions, and the natural secretion of the “master” hormone GH (growth hormone). GPC in the cytoplasm generally complements the actions of PS in the membranes. Like PS, GPC supports NGF actions and is abundant in human breast milk.(11,15)
Acetyl-l-Carnitine (ALC), which resembles PS and GPC in its capacity to conserve NGF receptors. ALC supports the mitochondrial pathways that generate energy,(16) and its acetyl groups contribute to epigenetic gene regulation.(17) ALC also supports mood management in adults,(18) and behavior in children.(19)
DocosaHexaenoic Acid (DHA, an omega-3 fatty acid and crucial to cell membrane functions.(20) DHA is naturally anchored into the nerve cell membrane matrix by PS and other phospholipids, and is a major nutrient for keeping the matrix semi-fluid to allow the membrane’s catalytic proteins necessary freedom of movement. Derivatives of DHA called “protectins” also help protect the brain against damage.(21) Dietary DHA deficiency is linked to difficulties with memory, learning, behavior and mood.(20)
L-Taurine, a potent antioxidant with nerve transmitter activity and a unique electrochemical buffering capacity that provides a unique form of protection for the brain.(22)
Vitamin C and Vitamin E, two major natural antioxidants that complement each other: C protects the cell water phase while E protects the cell membranes.(3) Vitamin C is highly concentrated in the brain, is a nerve transmitter cofactor, and likely helps regulate brain energetics.(23) This formula provides vitamin E as mixed tocopherols, to help improve the dietary intake ratio of gamma- to alpha-tocopherol.(24)
Vitamin B12, which is important for cognition(25) and works together with the formula’s other nutrients to help control homocysteine, a likely risk factor for brain dysfunction.(26) This formula provides a hefty allowance of B12 as hydroxocobalamin, the safest dietary form.
Vitamins B1, B2, B6 and Folate, provided in their metabolically activated as well as their more common supplement forms, to facilitate their metabolic utilization.(27)
Magnesium, a mineral nutrient essential to the healthy maintenance of ATP levels in cells.(28) Magnesium also helps to balance brain calcium metabolism. Nutrients Support the Brain’s Adaptability (“Plasticity”) Just within the past decade, neuroscientists discovered that the human brain is far more dynamic and adaptable than was previously assumed. This dynamic capacity for adaptation is called brain plasticity or neuroplasticity.(29) The human brain has such plasticity that the visual cortex can turn over as much as 7% of its synapse connections each week.(30) Making new synapses requires making new cell membrane mass, which requires energy. Measurable declines in memory-cognitive functions or sensory-motor functions are linked to loss of synapses and breakdown of mitochondrial functions.(2,31) By feeding into the brain’s capacities to produce and use energy, Brain NRG supports neuroplasticity and overall brain vitality.
This formula is suitable for the young, middle-aged or elderly. For anyone who loses things too often or cannot stay focused on the job at hand. For children who are excessively active or cannot seem to follow their parents’ directions. For healthy people who are facing intensive life challenges and looking to further sharpen their mental performance. Brain NRG is at the cutting edge of brain nutrition, generously endowed with clinically proven nutrients that are cost-effective and safe to take over the long term. Highest Quality Nutrients for Greatest Brain Benefits
This formula provides the best quality brain nutrients available, in a scientifically rational combination that optimizes efficacy, safety, convenience and affordability. The nutrients in Brain NRG have been carefully validated for their purity and freedom from contamination. The product was manufactured following Good Manufacturing Practices (cGMP), to ensure accurate label conformance and full shelf life. The ortho molecular character of this formula makes it especially safe and well tolerated as a dietary supplement.
Suggested usage is 1 capsule per 30 pounds body weight, taken after meals, to a maximum 4 capsules per day. Intakes up to 8 capsules per day or higher may give additional benefit. Particularly when combined with a healthy lifestyle that includes mental and physical exercise, Brain NRG is a prudent choice for anyone seeking optimal mental performance.**
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Each bottle of Nutrivene Brain NRG contains 120 vegetarian capsules.
Four capsules provide: 300 mg of Vitamin C, 30 IU of Vitamin E, 35 mg of Thiamin, 25 mg of Riboflavin, 50 mg of Niacinamide, 24 mg of Vitamin B6, 400 mcg of Folate, 1000 mcg of Vitamin B12, 300 mcg of Biotin, 60mg of Pantothenic acid, 40 mg of Magnesium, 88 mg of DHA, 150 mg of PhosphatidylSerine, 150 mg of GPC, 400 mg of AcetylCarnitine, 90 mg of CoEnzyme Q10, 80 mg of NAC, 40 mg of Alpha Lipoic Acid and 100 mg of Taurine.
Other ingredients: vegetarian capsule (cellulose), microcrystalline cellulose, magnesium stearate, silicon dioxide.
Scientific References 1. Jolivet R, Magistretti P, Weber B. Frontiers in Neuroenergetics 2009;1:1-10; 2. Kidd PM. Altern Med Rev 2005;10:268-293; 3. Alberts B, Johnson A, Lewis J, others. Molecular Biology of the Cell (Fourth Edition). New York: Garland Science;2002; 4. Nadeau S, Ferguson T, Valenstein E, others. Medical Neuroscience. Philadelphia, PA: Medical Neuroscience; 2004; 5. Pauling L. Science 1968;160:265-271; 6. Spindler M, Beal M, Henchcliffe C. Neuropsychiatric Disease and Treatment 2009;5:597-610; 7. Quinzii C, Lopez L, Naini A, others. Biofactors 2008;32:113-118; 8. Packer L, Tritschler H, Wessel K. Free Radical Biology and Medicine 1997;22:369-378; 9. Suh J, Moreau R, Heath S, others. Redox Reports 2005;10:52-60; 10. Carlson D, Smith A, Fischer S, others. Alternative Medicine Review 2007;12:343-351; 11. Kidd PM. PS (PhosphatidylSerine), Nature’s Brain Booster (Second Edition). St. George, UT: Total Health Communications; 2007; 12. Crook TH, Tinklenberg J, Yesavage J, others. Neurology 1991;41:644-649; 13. Starks M, Starks S, Kingsley M, others. Journal of the Intl Society of Sports Nutrition 2008;5:11-15; 14. Tuszynski M, Thal L, Pay M, others. Nature Medicine 2005;11:551-555; 15. Kidd PM. GPC (GlyceroPhosphoCholine), Mind-Body Power for Active Living and Healthy Aging. St. George, UT: Total Health Communications;2007; 16. Furlong J. Alternative Medicine Review 1996;1:85-93; 17. Madiraju P, Pande S, Prentki M, others. Epigenetics 2009;4:399-403; 18. Soczynska J, Kennedy S, Chow C, others. Expert Opinions on Investigative Drugs 2008;17:827-843; 19. Torrioli M, Vernatocola S, Peruzzi L, others. American Journal of Medical Genetics Part A 2008;146A:803-812; 20. Kidd PM. Alternative Medicine Review 2007;12:207-227; 21. Lukiw W, Bazan N. Journal of Nutrition 2008;138:2510-2514; 22. Oja S, Saransaari P. Proceedings of the Western Pharmacological Society 2007;50:8-15; 23. Castro M, Beltran F, Brauchi S, others. Journal of Neurochemistry 2009;209:423-440; 24. Gutierrez A, de Serna D, Robinson I, others. Metabolism 2009;58:469-478; 25. Wang HX, Wahlin A, Basun H, others. Neurology 2001;56:1188-1184; 26. Dos Santos E, Busanello E, Miglioranza A, others. Metabolic Brain Diseses 2009;24:257-269; 27. Snowdon DA, Tully CL, Smith CD, others. American Journal of Clinical Nutrition 2000;71:993-998; 28. Wells I. Canadian Journal of Physiology and Pharmacology 2008;86:16-24; 29. Doidge N. The Brain That Changes Itself. New York: Viking (Penguin Group);2007; 30. Stettler D, Yamahachi H, Li W, others. Neuron 2006;49:877-887; 31. Kidd P. Alternative Medicine Review 2008;13:85-115.
*Parris Kidd, PhD earned his degree at the University of California at Berkeley and entered the dietary supplement field in 1983. He has developed a great variety of dietary supplements and has specialized in brain nutrients since 1994. His website is www.dockidd.com.
**These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.