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What is Down syndrome?

Trisomy 21, or Down syndrome, is the most common chromosomal abnormality. Unlike other congenital conditions that have a deletion or mutation, individuals with Down syndrome have an extra chromosome 21. This extra chromosome causes “overexpression” of genes that change metabolism and function of antioxidants, amino acids, digestive enzymes, and other essential nutrients. Consequently, growth and developmental patterns may be negatively impacted in children with Down syndrome. Specific disturbances in metabolic pathways attributable to gene overexpression in Down syndrome include: Superoxide dismutase (SOD): With the increased production of SOD, other enzymes are unable to keep up with the detoxificaton of the free radical, hydrogen peroxide. The excess hydrogen peroxide accumulates in the cells and tissues causing oxidative stress and apoptosis (programmed cell death). SAM Cycle: The overexpression of the enzyme cystathionine beta synthase (CBS) disrupts homocysteine metabolism so that methionine (folate dependent) is not resynthesized. Methionine is required for the production of S-adenosylmethionine (SAM), a methyl donor that contributes to the synthesis of neurotransmitters (chemical messingers that nerve cells use to communicate with each other in the brain affecting mood, behavior hunger, sleep, etc.) and cell membrane components. Connective Tissue Issues: The gene associated with collagen expression is located on the 21st chromosome and may be responsible for the presence of hypotonia (poor muscle tone) issues common in Down syndrome.

What is Nutrivene-D?

Nutrivene-D is a nutritional supplementation program designed for individuals with Down syndrome. The program includes a Daily Supplement, Daily Enzyme, and NightTime Formula. Nutrivene-D Daily Supplement consists of vitamins, minerals, amino acids, and other essential nutrients that your child may need throughout the day. Children with Down syndrome may be deficient in digestive enzymes and experience malabsorption problems. Supplementing with digestive enzymes may help your child better absorb nutrients from his or her daily intake of foods and dietary supplements. Premature aging,lower growth rates, and sleep disturbances are also common in Down syndrome. The NightTime Formula provides nutrients needed for normal physiological function between the evening and morning meals.

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